Scrutiny of chemical triclosan could lead to FDA rules by 2018
Major manufacturers call it a powerful germ-killing ingredient for soaps, toothpastes and deodorants, but Susan Kriznik won't allow the man-made chemical triclosan on her shelves at home.
An infection prevention manager at Allegheny General Hospital, she has plenty of company in avoiding products with the antibacterial agent, which federal regulators have put under tougher scrutiny as it shows up in more consumer health and household goods.
“It's the actual time you spend cleaning your hands, with the friction, that actually removes the germs,” Kriznik said.
Western Pennsylvania's biggest hospital systems — UPMC, Allegheny Health Network and Excela Health — sidestep soaps that use triclosan. Patient safety managers question its effectiveness, side effects and impact on bacterial resistance.
Manufacturers insist there is no proof the chemical causes bodily harm.
At the Washington-based American Cleaning Institute, a trade group for makers of cleaning products, spokesman Brian Sansoni said the chemical has proved safe and effective in health care settings for more than 40 years.
Some scientists disagree.
“Are antibacterial soaps better than regular soaps? No. There's absolutely no evidence,” said Kishore Alugupalli, an assistant professor of microbiology and immunology at Thomas Jefferson University in Philadelphia. “I'm against any antibacterial substance that is not necessary.”
The Food and Drug Administration cast a spotlight in December on triclosan, which emerged as a surgical scrub in the 1970s. It went mainstream as an additive to consumer products in the 1990s and appears in many liquid hand and dishwashing soaps, mouthwashes and cosmetics, among other goods.
Some manufacturers incorporate the chemical into durable items such as earplugs, cutting boards, bath towels and socks. Three in four Americans surveyed in a decade-old study had the chemical in their urine, according to the National Center for Biotechnology Information.
Animal studies suggest long-term exposure to triclosan, which can seep into the bloodstream, could change how hormones work in the human body. Other research raises the prospect that triclosan could help bacteria evolve and become resistant to antibiotics, which might undermine the usefulness of standard medicines, the FDA found.
An FDA proposal would require antibacterial soap makers to prove their consumer products are safe for regular use and more effective than plain soap in preventing illnesses or infections. The agency plans to rule on that proposal by Sept. 15, 2016, spokeswoman Andrea Fischer said.
Manufacturers that don't comply would need to reformulate products or relabel them, according to the agency. The rule would apply to goods containing triclosan and other antibacterial agents such as triclocarban in bar soaps.
“It's pretty clear they're intending to do away with (triclosan) at the consumer level,” said Donald W. Schaffner, a food science professor at Rutgers University in New Brunswick, N.J. “My concern is that use of the product in food service may get caught up in that. It is one very useful tool at our disposal to reduce the risk of food-borne pathogens in food service.”
Science of hygiene
The FDA said it's studying whether triclosan at low concentrations found in consumer products is better at keeping people healthy than conventional scrubbing with basic soap.
“It's one of the most researched, reviewed and regulated ingredients available today,” Sansoni said. His American Cleaning Institute has said evidence and practices do not show triclosan has hormonal effects in humans or that it contributes to antibiotic resistance.
Instead, the institute argues, triclosan can curb bacteria during hand washing, which might reduce infections.
The science behind hand cleaners is subtle, researchers said. They said popular alcohol-based sanitizer gels such as Purell act like a sledgehammer, destroying the bacteria's membrane and killing them immediately. Germs have no chance to develop a resistance to alcohol, a natural agent, they said.
“I actually think they're a very important part of hand hygiene,” said Dr. Carlene Muto, medical director for infection control at Downtown-based UPMC. “An alcohol-based product is an instant kill.”
Triclosan works more slowly and requires longer contact, starving bacteria by putting them under stress, said Alugupalli, the Thomas Jefferson University professor. He said that process allows the micro-organisms to develop mutations that can lead to antibiotic resistance.
UPMC hospitals skirt those issues by using a simple soap in some settings and a specialized product known as chlorhexidine gluconate, or CHG, in others. CHG uses a slow-release approach that stays on the hands long after a good scrub, Muto said.
Kriznik said Allegheny Health Network hospitals, including Allegheny General in the North Side, use soaps without triclosan. Greensburg-based Excela Health uses mostly triclosan-free products, including CHG, patient safety director Kathleen Rosatti said.
Ongoing FDA reviews of triclosan should lead to new rules for the chemical's use in health care settings by Jan. 15, 2018, according to the agency.
Adam Smeltz is a Trib Total Media staff writer. He can be reached at 412-380-5676 or firstname.lastname@example.org.
Show commenting policy
TribLive commenting policy
You are solely responsible for your comments and by using TribLive.com you agree to our Terms of Service.
We moderate comments. Our goal is to provide substantive commentary for a general readership. By screening submissions, we provide a space where readers can share intelligent and informed commentary that enhances the quality of our news and information.
While most comments will be posted if they are on-topic and not abusive, moderating decisions are subjective. We will make them as carefully and consistently as we can. Because of the volume of reader comments, we cannot review individual moderation decisions with readers.
We value thoughtful comments representing a range of views that make their point quickly and politely. We make an effort to protect discussions from repeated comments either by the same reader or different readers.
We follow the same standards for taste as the daily newspaper. A few things we won't tolerate: personal attacks, obscenity, vulgarity, profanity (including expletives and letters followed by dashes), commercial promotion, impersonations, incoherence, proselytizing and SHOUTING. Don't include URLs to Web sites.
We do not edit comments. They are either approved or deleted. We reserve the right to edit a comment that is quoted or excerpted in an article. In this case, we may fix spelling and punctuation.
We welcome strong opinions and criticism of our work, but we don't want comments to become bogged down with discussions of our policies and we will moderate accordingly.
We appreciate it when readers and people quoted in articles or blog posts point out errors of fact or emphasis and will investigate all assertions. But these suggestions should be sent via e-mail. To avoid distracting other readers, we won't publish comments that suggest a correction. Instead, corrections will be made in a blog post or in an article.
- Pennsylvania’s new online voter registration racks up 5,000 applicants
- Shooting that killed Winchester Thurston grad surprised witnesses
- CCAC solar panels to power up after decade of delay
- Uniontown first responders use antidote to revive man who overdosed on heroin
- Gameday: Pirates at Brewers, Sept. 3, 2015
- Hacker stuns Dayton family with computer takeover
- Pittsburgh schools scramble for money amid Pa. budget impasse
- North Allegheny, Ellis School hope to defend field hockey titles
- In reworking contract, Steelers WR Brown gets hefty pay raise
- Steelers trying to get missing defensive pieces on field
- Pitt to open ACC play vs. Syracuse at home