Colorado center Matt Duchene left the Avalanche's game against San Jose with a left knee injury and did not return.
Duchene was hurt on the opening shift Saturday when he collided with teammate Jamie McGinn near the Sharks blue line.
He fell to the ice and then gingerly skated to the bench.
Duchene has 23 goals and a team-leading 70 points in 70 games this season.
He missed three games in November after suffering an oblique injury against Florida.
Coyotes' Smith remains out
Coyotes goalie Mike Smith won't be on the ice to test his lower-body injury until at least the end of next week, but coach Dave Tippett is hoping he will be able to return to the lineup before the end of the regular season.
Smith, who was injured late in a 4-3 overtime loss to the Rangers on Monday, is back to working out off the ice and will have his injury re-evaluated at the end of the week.
— Wire reports
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